- Transcription factor, Nucleosome remodelling, Topoligacally associating domains, human innate immune cells, monocyte, macrophage
Role in the COST action
Contribution to the Project
I am a molecular biologist with interest in annotation of human chromosomal cis-acting regulatory module DNA sequences. I have produced data on a thousands of epigenetically dynamic transcription promoters and enhancers using primary healthy human white blood cells exposed to beta-glucans, lipopolysaccharide and glucocorticoids. Steroids and other nuclear receptor research interest me very much, as do bHLH and bZIP transcription factors and the signals they integrate and initiate on chromosomes. In summary, I am interested in molecular interactions within chromosomes and how this relates to signalling to the genome and the transcriptional output from the genome.