Use Case 2 HOW TO FIND DNA-TF / COACTIVATOR-TF ASSOCIATIONS THAT REGULATE TG
Which DNA binding Transcription Factors (dbTFs) interact with a particular coactivator and regulate the transcription of target genes (TGs)?
The transcriptional coactivator CITED2 (Cbp/p300-interacting transactivator 2) is involved in many biological processes, such as cell differentiation and development of several tissues, (e.g., cardiac, adrenal, and neural tissues) (PMID: 21764344). Regulation of gene transcription can be accomplished through the interaction of a DNA binding TF (dbTF) with coactivator proteins (coTF), with the dbTF interacting with these coactivators important for the correct functioning of the target genes.
QUERY AND RESULTS
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